A molecular geneticist crosses two heterozygous individuals (Aa) for a gene affecting disease susceptibility. If 160 offspring are produced, and the disease requires genotype aa, how many offspring are expected to be disease-free (genotype AA or Aa), assuming Mendelian inheritance and correct phenotypic observation?

Thu, 16 Apr 2026 06:50:14 +0000

A molecular geneticist crosses two heterozygous individuals (Aa) for a gene linked to disease susceptibility. If 160 offspring are produced, how many are expected to be disease-free—genetically possessing either AA or Aa genotypes—under Mendelian inheritance? This classic cross reveals foundational principles of genetic transmission, with clear patterns visible even to curious learners aiming to understand hereditary risk. While pregnancy and genetics spark broad interest, precise calculations help demystify inheritance patterns and clarify what it means to be disease-resistant in combinational terms. ### Why A molecular geneticist crosses two heterozygous individuals (Aa) for a gene affecting disease susceptibility. If 160 offspring are produced, and the disease requires genotype aa, how many offspring are expected to be disease-free (genotype AA or Aa), assuming Mendelian inheritance and correct phenotypic observation? Modern genetics communities increasingly focus on how gene combinations shape disease risk, especially for inherited conditions. A common experimental cross involves heterozygous parents (Aa × Aa), where observable outcomes follow Mendelian ratios. With 160 offspring generated under ideal conditions, the math reveals predictable results. Educators emphasize this model not to sensationalize, but to empower readers with accurate, accessible insight—bridging curiosity and scientific understanding in a safe, mobile-friendly format. #### Punnett Square Basics: How the Cross Works