C: Block histamine H2 receptors

Sat, 18 Apr 2026 09:33:52 +0000

Understanding H2 Histamine Receptors: Blocking Mechanisms and Clinical Significance Histamine plays a crucial role in various physiological processes, including immune responses, gastric acid secretion, and neurotransmission. Among the histamine receptor subtypes, H2 receptors are particularly important in regulating gastric acid production, making them a key target for pharmaceutical intervention. This article explores block histamine H2 receptors—how these blockers work, their medical applications, and their evolving role in modern medicine. ### What Are H2 Histamine Receptors? H2 histamine receptors (H2R) are G-protein coupled receptors predominantly expressed in the parietal cells of the stomach lining. When histamine binds to H2 receptors, it stimulates the enzyme gastrinogenic adenylate cyclase, leading to increased cyclic AMP (cAMP) and enhanced secretion of hydrochloric acid (HCl). This mechanism is central to gastric acid regulation and supports digestion and mucosal defense.