B: CYP3A4

Sat, 18 Apr 2026 09:33:52 +0000

Understanding CYP3A4: The Liver Enzyme Critical to Drug Metabolism In the intricate world of pharmacology and drug metabolism, CYP3A4 stands out as one of the most important enzymes in the human body. This cytochrome P450 enzyme plays a pivotal role in breaking down a wide variety of medications, making it a key player in determining drug efficacy and safety. Whether you're a healthcare professional, researcher, or a patient seeking clearer insight into how medicines work, understanding CYP3A4 is essential. ### What is CYP3A4? CYP3A4 is a member of the cytochrome P450 superfamily, a group of enzymes primarily located in the liver and intestines. It is notably responsible for metabolizing approximately 50% of all clinically used drugs. These include statins (cholesterol-lowering drugs), immunosuppressants, antidepressants, antiarrhythmics, and many others. Beyond pharmaceuticals, CYP3A4 also processes natural compounds from food, environmental toxins, and endogenous steroids, underscoring its broad physiological relevance.