B) They promote chronic inflammation through the senescence-associated secretory phenotype (SASP)

Fri, 17 Apr 2026 23:34:05 +0000

**Why Chronic Inflammation and the SASP Matter—What You Should Know in 2025** Why are experts increasingly turning attention to the senescence-associated secretory phenotype, or SASP, in discussions about long-term health and aging? The rise of this topic reflects growing awareness of how cellular processes contribute not only to aging but also to persistent inflammation—a key driver in many chronic conditions. At the heart of this discussion is B) They promote chronic inflammation through the senescence-associated secretory phenotype (SASP), a natural yet impactful biological mechanism with far-reaching implications for wellness across the US population. Recent scientific findings show that as cells enter senescence—a natural state of growth arrest—they shift their secretory profile, releasing pro-inflammatory molecules collectively known as SASP. This response is part of the body’s attempt to manage tissue damage, but when uncontrolled, it fuels low-grade inflammation linked to aging and disease. Recognizing this pathway offers insight into how inflammation may silently accumulate over years, influencing conditions like arthritis, cardiovascular disease, and metabolic disorders. Understanding how SASP promotes chronic inflammation underscores the complex balance between cellular repair and long-term health. While inflammation is essential for immune defense, persistent SASP-driven signaling can tip the scale toward tissue damage and reduced resilience. This awareness is especially relevant as the US population ages and demand grows for preventive strategies that address root biological causes—not just symptoms.